中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/34958
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    题名: An Open-Label, Multicentre Study of Levocetirizine for the Treatment of Allergic Rhinitis and Urticaria in Taiwanese Patients
    作者: (Sheen-Yie Fang);(Diahn-Warng Perng);(J. Yu-Yun Lee);(Ding-Yu Lin)*;黃志揚(Chih-Yang Huang)*
    贡献者: 基礎醫學研究所
    关键词: allergic rhinitis;urticaria;levocetirizine;patient perception;persistent allergic rhinitis
    日期: 2010
    上传时间: 2010-11-19 17:09:53 (UTC+8)
    摘要: Levocetirizine has been shown in observational studies in the west as an effective and
    satisfactory therapy for patients with allergic respiratory and skin disease. An open-label,
    multicentre observational study to investigate the patients’ perception of levocetirizine in the
    treatment of allergic rhinitis (AR) and urticaria in Taiwanese patients. Three hundred and
    thirty-three patients (236 AR and 97 urticaria patients) attending out-patient clinics of
    medical centres across Taiwan. Patients were treated with levocetirizine 5mg once daily (AR
    patients for 2-4 weeks and urticaria patients for 2-6 weeks) and at the end of treatment
    evaluated for symptoms of disease, perception of change in symptoms, global efficacy and
    tolerability, global preference over previous antiallergic treatment, change in quality of
    sleep/daily activities, and safety and adverse events (AEs). Levocetirizine markedly improved
    the symptoms of AR and urticaria; with 70%-75% of AR patients and 60%-80% of urticaria
    patients reporting complete or marked improvements in individual symptoms. Asthma
    symptoms were completely or markedly improved in 44% of patients with AR and
    concomitant asthma. The majority of patients were satisfied with levocetirizine therapy and
    50%-70% indicated preference for levocetirizine over previous therapy. Overall, 50%-74% of
    all patients perceived improvements in quality of sleep/daily activities and 50%-65% of the
    patients rated the onset of action for levocetirizine as very rapid or rapid. Somnolence was the
    most common AE, reported by 7.4% of AR and 7.0% of urticaria patients. The results of this
    study indicated Levocetirizine is an effective and satisfactory therapy for the management of
    allergic respiratory and skin disease in Taiwanese subjects.
    關聯: CHINESE JOURNAL OF PHYSIOLOGY 53(4):199-207
    显示于类别:[基礎醫學研究所] 期刊論文

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