中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/34948
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    題名: Effects of 17 beta-estradial on cardiac apoptosis in ovariectomized rats
    作者: (Cher-Ming Liou);(Ai-Lun Yang);郭家驊;丁化(Hua Ting)*;黃志揚(Chih-Yang Huang)*;李信達(Shin-Da Lee)*
    貢獻者: 物理治療學系;基礎醫學研究所
    關鍵詞: heart;apoptosis;menopause;ovariectomy;oophorectomy;caspase;estrogen;estradiol
    日期: 2010-08
    上傳時間: 2010-11-19 16:55:59 (UTC+8)
    摘要: Objectives Cardiac apoptosis was found in ovariectomized rats without ischemia. Limited information regarding the protective effects of
    17b-estradiol (E2) on cardiac Fas-dependent and mitochondria-dependent apoptotic pathways after post-menopause or bilateral oophorectomy
    in women was available.
    Methods Forty-eight female Wistar rats at 6-7 months of age were divided into sham-operated group (Sham, n?16) and bilateral
    ovariectomized group (n?32). After 4 weeks of operation, rats in ovariectomized group were injected intraperitoneally with either saline
    (OVX, n?16) or 10mg/kg/day 17b-estradiol (E2) for 10 weeks (OVX-E2, n?16). The excised hearts were measured by Hematoxylin-eosin
    staining, DAPI staining, positive TUNEL assays, and Western Blotting.
    Results 17b-estradiol (E2) decreased OVX-induced cardiac widely dispersed TUNEL-positive apoptotic cells. 17b-estradiol (E2)
    decreased OVX-induced TNF-alpha, Fas ligand (Fas L), Fas death receptors (Fas), Fas-associated death domain (FADD), activated caspase
    8, and activated caspase 3 (Fas pathways). 17b-estradiol (E2) decreased OVX-induced proapoptotic t-Bid, Bax, Bax-to-Bcl2 ratio, Bax-to-
    BclXL ratio, activated caspase 9, and activated caspase 3 as well as increased anti-apoptotic Bcl2 and Bcl-XL relative to OVX (mitochondria
    pathway).
    Conclusions Our findings suggest that chronic 17b-estradiol (E2) treatment can prevent ovariectomy-induced cardiac Fas-dependent and
    mitochondria-dependent apoptotic pathways in rat models. The findings may provide one of possible mechenisms of 17b-estradiol (E2) for
    potentially preventing cardiac apoptosis after bilateral ovariectomy or menopause.
    關聯: CELL BIOCHEMISTRY AND FUNCTION 28(6):521-528
    顯示於類別:[物理治療學系暨復健科學碩士班] 期刊論文

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