Cardiac Contractile Dysfunction and Apoptosis in Streptozotocin-Induced Diabetic Rats Are Ameliorated by Garlic Oil Supplementation

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Title:	Cardiac Contractile Dysfunction and Apoptosis in Streptozotocin-Induced Diabetic Rats Are Ameliorated by Garlic Oil Supplementation
Authors:	歐秀中(Hsiu-Chung Ou);(Bor-Show Tzang);(Mu-Hsin Chang);(Cheng-Tzu Liu);(Hui Wen. Liu);李宗貴(Chong-Kuei Lii);包大?(Da-Tian Bau);趙蓓敏(Pei-Min Chao);郭薇雯(Wei-Wen Kuo)*
Contributors:	物理治療學系;臨床醫學研究所;營養學系
Keywords:	Diabetes-induced cardiomyopathy;echocardiography;oxidative stress;superoxide dismutase;garlic oil
Date:	2010
Issue Date:	2010-11-19 16:55:44 (UTC+8)
Abstract:	Previous studies have suggested that garlic oil could protect the cardiovascular system. However, the mechanism by which garlic oil protects diabetes-induced cardiomyopathy is unclear. In this study, streptozotocin (STZ)-induced diabetic rats received garlic oil (0, 10, 50, or 100 mg/kg of body weight) by gastric gavage every 2 days for 16 days. Normal rats without diabetes were used as control. Cardiac contractile dysfunction examined by echocardiography and apoptosis evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay were observed in diabetic rat hearts. Additionally, a shift in cardiac myosin heavy chain (MHC) gene expression from α- to β-MHC isoform, decreased levels of superoxide dismutase-1 (SOD-1) and cardiac α-actin, and elevated cardiac thiobarbituric acid reactive substances (TBARS) and caspase- and p38-NFκB-leading apoptosis signaling activities were demonstrated in diabetic hearts. However, these diabetes-related cardiac dysfunctions were almost dose-dependently ameliorated by garlic oil administration. In conclusion, garlic oil possesses significant potential for protecting hearts from diabetes-induced cardiomyopathy.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58(17):9563-9571
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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