中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/34936
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    题名: Ameliorate Effects of Li-Fu Formula on IL-6-mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-cholesterol Diet
    作者: (Yi-Chang Cheng);(Chieh-His Wu);郭薇雯(Wei-Wen Kuo);(James A. Lin);(Hsueh-Fang Wang);(Fuu-Jen Tsai);(Chang-Hai Tsai);黃志揚(Chih-Yang Huang)*;(Tsai-Ching Hsu);(Bor-Show Tzang)*
    贡献者: 生物科技學系;基礎醫學研究所
    关键词: heart;hypercholesterol;hypertrophy;Li-Fu formula
    日期: 2010
    上传时间: 2010-11-19 16:39:59 (UTC+8)
    摘要: Hypercholesterolemia diets are considered as major sources to cause cardiac
    hypertrophy. This study intends to evaluate the effects of Li-Fu formula on cardiac
    hypertrophy induced by hypercholesterolemia diet. Twenty-four male Golden Syrian
    hamsters at 3 months of age were randomly divided into Control, Cholesterol and
    Li-Fu formula groups and fed with different experimental diets for 2 months.
    Histopathological analysis and western blotting were performed to measure the
    myocardial architecture, and expressions of different cardiac hypertrophy-associated
    molecules in the excised left ventricle from hamsters. The ratios of Whole heart
    weight (WHW)/Body weight (BW) and Left ventricle weight (LVW)/BW were
    significantly higher in the Cholesterol group but significantly lower in the Li-Fu
    formula group. The protein levels of both ANP and BNP were significantly increased
    in the Cholesterol group but significantly reduced in the Li-Fu formula group.
    Additionally, significantly increased interleukin (IL)-6, STAT3, MEK5, p-ERK5 and
    non-cardiomyocyte proliferate signal molecules such as p-MEK and p-ERK, were
    detected in the Cholesterol group but significantly reduced in the Li-Fu formula group.
    Notably, no significant variations of inflammatory signaling molecules, including
    p-P38 and p-JNK, were detected in all groups. Our experimental results demonstrate
    the significant reductions of cardiac hypertrophy and related eccentric hypertrophy
    signaling, non-cardiomyocyte proliferate signaling in the excised left ventricle of
    hamsters from the Li-Fu formula. We suggested the protective effects of Li-Fu
    formula on cardiac hypertrophy that may be useful in prevention or treatment of
    hypertrophy-associated cardiovascular diseases.
    關聯: Evidence-based Complementary and Alternative Medicine (1):1-9
    显示于类别:[生物科技學系暨碩士班] 期刊論文

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