Ursolic acid induces allograft inflammatory factor-1 expression via nitric oxide-related mechanism and increases neovascularization

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Title:	Ursolic acid induces allograft inflammatory factor-1 expression via nitric oxide-related mechanism and increases neovascularization
Authors:	(Ai-Wei Li);(Ta-Liang Chen);(Chun-Ming Shih);(Chun-Yao Huang);(Nai-Wen Tsao);(Nen-Chung Chang);(Po-Hsun Huang);陳永祥(Yung-Hsiang Chen);(Tsorng-Harn Fong);(Feng-Yen Lin)
Contributors:	中西醫結合研究所
Keywords:	Allograft inflammatory factor-1;Chinese herbal medicine;Endothelial nitric oxide synthase;Neovascularization;Ursolic acid
Date:	2010-12
Issue Date:	2010-11-19 16:03:50 (UTC+8)
Abstract:	Ursolic acid (UA), a triterpenoid compound found in plants that used in the human diet and in medicinal herbs, possesses a wide range of biological benefits including anti-oxidative, anti-inflammation, and anti-carcinogenesis effects. Endothelial expression of allograft inflammatory factor-1 (AIF-1) mediates vasculogenesis and nitric oxide (NO) produced by endothelial NO (eNOS) represents a vascular protection principle. It is unclear whether UA affects the neovascularization mediating by AIF-1 and eNOS expression. This study investigated the effects and mechanisms of UA on angiogenesis in vivo in hind limb ischemic animal models and in vitro in human coronary artery endothelial cells (HCAECs). In this study, we tried to explore the impact of UA on ECs activities in vitro in human coronary endothelial cells, vascular neovasculogenesis in vivo in mouse hind-limb ischemia model, and the possible role of AIF-1 in the vasculogenesis. The results demonstrated that UA enhances collateral blood flow recovery through induction of neovascularization in a hind limb ischemia mouse model. The in vitro data show that UA increases tube formation and migration capacities in human endothelial cells; exposing HCAECs to UA increased AIF-1 expression through NO-related mechanism. Moreover, UA administration increased capillary density, eNOS and AIF-1 expression in ischemic muscle. These findings suggest that UA may act as a therapeutic agent in the induction of neovascularization and provide a novel mechanistic insight into the potential effects of UA on the ischemic vascular diseases.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58(24):12941-12949
Appears in Collections:	[Graduate Institute of Integrated Medicine] Journal articles

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