A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 期刊論文 > Item 310903500/3453

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题名:	A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients
作者:	邱昌芳(Chang-Fang Chiu);蔡銘修(Ming-Hsui Tsai);曾憲彰(Hsien-Chang Tseng);王政力(Cheng-Li Wang);蔡輔仁(Fuu-Jen Tsai);林正介(Cheng-Chieh Lin);包大靝(Da-Tian Bau)*
贡献者:	醫學院醫學系學士班內科學科;中國附醫內科部血液腫瘤科
关键词:	ERCC6;Polymorphism;Oral cancer;Carcinogenesis
日期:	2008-05
上传时间:	2009-08-20 18:46:52 (UTC+8)
摘要:	The DNA repair gene ERCC6, an important caretaker of the overall genome stability, is thought to play a role in the development of human malignancy. However, the polymorphic variants of ERCC6, has never been reported about their association with oral cancer susceptibility. In this hospital-based case-control study, the association of ERCC6 codon 399, 1097 and 1413 polymorphisms with oral cancer risk in a Central Taiwanese population was first investigated. In total, 292 patients with oral cancer and 290 age- and gender-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. We found a significant different distribution in the frequency of the ERCC6 codon 399 genotypes, but not the ERCC6 codon 1097 or 1413 genotypes, between the oral cancer and control groups. Those who had homozygous A/A or heterozygous A/G at ERCC6 codon 399 showed a 1.82- and 1.22-fold (95% confidence interval = 1.19–2.79 and 0.83–1.78, respectively) increased risk of oral cancer compared to those with G/G. As for ERCC6 codon 1097 or 1413, there was no difference in distribution between the oral cancer and control groups. Gene-environment interactions with smoking and betel quid chewing, but not alcohol drinking, were significant for ERCC6 polymorphisms. ERCC6 codon 399, G/A + A/A ever user groups exhibited an increased risk of 2.36 (95% CI = 1.36–4.10) for smoking and 2.72 (95% CI = 1.31–5.63) for betel quid chewing. Our results firstly suggest that the heterozygous and homozygous A allele of the ERCC6 codon 399 may be associated with the development of oral cancer and may be a novel useful marker for primary prevention and anticancer intervention.
關聯:	ORAL ONCOLOGY 44(6):582~586
显示于类别:	[醫學系] 期刊論文

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