中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/3452
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    題名: A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan
    作者: 邱昌芳(Chang-Fang Chiu);王仲興(Chung-Hsing Wang);王政力(Cheng-Li Wang);林正介(Cheng-Chieh Lin);許南榮(Nan-Yung Hsu);翁靖如;包大靝(Da-Tian Bau)*
    貢獻者: 醫學院醫學系學士班內科學科;中國附醫內科部血液腫瘤科
    關鍵詞: XRCC4;Polymorphism;Gastric cancer;Carcinogenesis
    日期: 2008-02
    上傳時間: 2009-08-20 18:46:52 (UTC+8)
    摘要: Background The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.
    Materials and Methods In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms’ association with gastric cancer susceptibility.
    Results We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47–9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.
    Conclusions Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
    關聯: ANNALS OF SURGICAL ONCOLOGY 15(2):514~518
    顯示於類別:[醫學系] 期刊論文

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