Association between transforming growth factor-β1 gene C-509T and T869C polymorphisms and rheumatic heart disease.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 臨床醫學研究所 > 期刊論文 > Item 310903500/3360

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/3360

题名:	Association between transforming growth factor-β1 gene C-509T and T869C polymorphisms and rheumatic heart disease.
作者:	周湘台(Hsiang-Tai Chou)*;陳建勳(Chien-Hsiun Chen);蔡長海(Chang-Hai Tsai);蔡輔仁(Fuu-Jen Tsai)
贡献者:	醫學院臨床醫學研究所;中國附醫內科部心臟科
日期:	2004-07
上传时间:	2009-08-20 18:38:00 (UTC+8)
摘要:	Background Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of a smoldering rheumatic process and a constant trauma to the mitral vlave or aortic valve by the turbulent flow in rheumatic heart disease (RHD). Transforming growth factor-β1 (TGF-β1) may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of RHD. However, the role of TGF-β1 genetic variant in RHD has not been studied. This case-controlled study was carried out to investigate the possible relationship between the TGF-β1 gene C-509T and T869C polymorphisms and RHD among the Chinese population in Taiwan. Methods A group of 115 patients with RHD documented by using echocardiography and 100 age- and sex-matched healthy control patients were studied. TGF-β1 gene C-509T and T869C polymorphisms were identified with polymerase chain reaction-based restriction analysis. Results A significant difference was seen in the distribution of genotypes between patients with RHD and control patients for either TGF-β1 C-509T polymorphism (P <.0001) or T869C polymorphism (P <.0001). The frequency of TGF-β1 C-509T CC genotype was lower in the RHD group than in the control group (χ2 = 19.05, P <.0001), which suggests that this genotype may confer protective effects against RHD. A significant difference was seen in the distribution of allelic frequency between patients with RHD and control patients for TGF-β1 T869C polymorphism (P = .04). The odds ratio (OR) for risk of RHD associated with TGF-β1 T869C T allele was 1.49 (95% CI, 1.02–2.19). Further categorization of patients with RHD into mitral valve disease and combined valve disease subgroups revealed no statistical difference in these gene polymorphisms when compared with the 2 subgroups. Conclusions Patients with RHD have a lower frequency of TGF-β1 C-509T CC genotype and a higher frequency of T869C T allele, which supports a role for the TGF-β1 gene C-509T and T869C polymorphisms in determining the risk/protection of RHD in Taiwan Chinese patients.
關聯:	AMERICAN HEART JOURNAL148(1):181~186
显示于类别:	[臨床醫學研究所] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	498	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....