中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/3358
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 29490/55136 (53%)
造访人次 : 1497164      在线人数 : 80
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CMUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/3358


    题名: Association of interleukin 1 beta and receptor antagonist gene polymorphisms with primary open-angle glaucoma
    作者: 周湘台(Hsiang-Tai Chou);施怡如(Shi YR);(Hsu Y);蔡輔仁(Fuu-Jen Tsai)*
    贡献者: 醫學院臨床醫學研究所;中國附醫內科部
    关键词: Primary open-angle glaucoma;Genetic polymorphism;Interleukin 1 beta;Interleukin 1 receptor antagonist
    日期: 2003-09
    上传时间: 2009-08-20 18:37:59 (UTC+8)
    摘要: Purpose: Genetic factors are known to play a role in the etiology of glaucoma. More specifically, the role of the immune system is highly suspected. We evaluated the association between 2 polymorphisms in the interleukin (IL) 1 beta gene (IL-1 promoter 511, IL-1 exon 5) and 1 polymorphism in the IL-1 gene receptor antagonist (IL-1Ra) intron 2 with primary open-angle glaucoma (POAG). Patients and Methods: Fifty-eight POAG patients and 105 healthy volunteers were enrolled in this study. Analysis based on polymerase chain reaction was used to resolve the 2 IL-1 polymorphisms and the IL-1Ra intron 2 polymorphism. Results: There were significant differences in the distribution of the IL-1 exon 5 polymorphism between the POAG patients and the control subjects (p < 0.05). The E2 allele of IL-1 exon 5 was more frequently found in POAG patients than in healthy patients (odds ratio: 4.224, 95% confidence interval = 1.135-15.717). The distributions of the other 2 polymorphisms, IL-1 promoter 511 and IL-1Ra intron 2, were not significantly different between the POAG patients and the healthy control group. Conclusions: The frequency of the E2 allele of the IL-1 exon 5 polymorphism was high in POAG patients. Therefore the E2 allele can be used as a marker to predict or search for the genetic causes of glaucoma in Chinese POAG patients. Furthermore, we have concluded that the other 2 polymorphisms (IL-1 promoter 511 and IL-1Ra) are not helpful in predicting Chinese POAG.
    關聯: DOCUMENTA OPHTHALMOLOGICA 217(5):358~364
    显示于类别:[臨床醫學研究所] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    13KbUnknown467检视/开启


    在CMUR中所有的数据项都受到原著作权保护.

    TAIR相关文章

     

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈