Comparative prevalence of plasma human herpesvirus 8 DNA in sexual contact and intravenous injection routes of HIV transmission.

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Title:	Comparative prevalence of plasma human herpesvirus 8 DNA in sexual contact and intravenous injection routes of HIV transmission.
Authors:	林振文(Lin Cheng Wen)*;張鈞萍(Chun-Pin Chang);吳芳鴦(Fang-Yang Wu);劉喬俐(Chao-Li Liou)
Contributors:	健康照護學院醫學檢驗生物技術學系;中國附醫檢驗醫學部
Keywords:	human herpesvirus 8;HIV;transmission model
Date:	2008-04
Issue Date:	2009-08-20 18:29:08 (UTC+8)
Abstract:	Detection of plasma human herpesvirus (HHV)-8 DNA correlates with antibodies to lytic HHV-8 antigens, being predictive of Kaposi's sarcoma in HIV-infected patients. We show that the prevalence of plasma HHV-8 DNA was 10.6% for HIV infection through sexual contact and 7.1% for HIV infection through intravenous injection. In addition, the prevalence of plasma HHV-8 DNA was significantly associated with male gender (9.4%) and HIV viral load below 1000 copies mL−1 (12.1%), but not age or CD4 cell count in HIV-infected patients. The study suggested that detection of plasma HHV-8 DNA could be important for monitoring replicating HHV-8 in HIV-infected patients, and may have use as a marker for the diagnosis of HHV-8 infection in blood-borne transmission.
Relation:	FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 52(3):428~430
Appears in Collections:	[Department of Medical Laboratory Science and Biotechnology ] Journal articles

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