微波加速合成芳香環及雜環微波加速合成芳香環及雜環

CMUR > College of Pharmacy > Graduate Institute of Pharmaceutical Chemistry > Theses & dissertations > Item 310903500/32624

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Title:	微波加速合成芳香環及雜環微波加速合成芳香環及雜環 Microwave-assisted Synthesis Aromatic and Heterocyclic Methanimidamide Derivatives and Antiproliferative Evaluation
Authors:	鄭光閔;Kaung-Min Cheng
Contributors:	藥學院藥物化學研究所碩士班
Keywords:	芳香胺;微波幫助;吡唑胺;醯胺;脒基化;甲醯化;三氯氧磷;aromatic amines;pyrazol-5-amines;microwave-assisted;amide;amidination;formylation;POCl3
Date:	2010
Issue Date:	2010-09-29 14:10:38 (UTC+8)
Abstract:	本論文主要是使用微波加速化學反應方法，有效地將芳香胺類及吡唑胺類在醯胺類溶劑及POCl3誘導下進行脒基化反應。脒基化產物是否有甲醯官能基之加成，決定於醯胺類化合物之解離速率，主要由醯胺基上氮原子之取代基立體或電子效應共同掌控。 A convenient and efficient microwave-assisted amidination were developed by reacting various primary amines including aromatic amines and pyrazol-5-amines with amide solvents and POCl3 coupling agent. Our results suggested that yielding formylation amidinyl pyrazole products might seem determinate by the dissociation of the substituting amides by means of the steric and electronic effect of the substitutents on the amides.
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Theses & dissertations

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