Traumatic brain injury (TBI) is a common cause induced severe brain damages. There are many controversals in clinical management for such condition. The outcome prediction is more difficult. Though several tools developed but precisely outcome prediction not available yet. There are many biomarkers mentioned before but no one can put into clinical practice. Matrix metalloproteinase 9 (MMP-9), one of the protein rich in supportive tissue over central nervous system, was mentioned to be potential in outcom prediction for neuron damage. There are many articles try to clarify the connection between MMP-9 and brain damages. Now we try to build up how the MMP-P convinced the outcome prediction in traumatic brain injuries. We correct the cerebro-spinal fluid from ventricular puncture during ventriculo-peritoneal shunt (VP shunt ) surgery for patients with hydrocephalus. Then we calculated the concentration of MMP-9 in CSF. Eighty-five patients were involved and the average concentration of MMP-9 in CSF is 1.172±0.859 ng/mL. The concentration is not influenced by several factors such as gender and age. It’s the first available data of MMP-9 concentration is CSF. We also collect the cerebrospinal fluid from 6 head injury patients received surgical intervention with external ventricular drainage insertion. After analysis, we found it that MMP-9 concentration elevated immediately after head injury. Besides, the concentration of MMP-9 decreased within 72 hours and became nearly within the normal range.
