電針對前列腺肥大患者排尿困難症狀之療效評估：隨機、單盲、對照試驗

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Title:	電針對前列腺肥大患者排尿困難症狀之療效評估：隨機、單盲、對照試驗 The effect of electroacupuncture on patient with benign prostate hyperplasia-induced voiding dysfunction：A single-blind Randomized Controlled Trial.
Authors:	游榮聖;Jung_Sheng Yu
Contributors:	中醫學院中西醫結合研究所碩士班
Keywords:	前列腺肥大;電針;排尿障礙。;Benign prostate hyperplasia (BPH);electroacupuncture;dysuria.
Date:	2010
Issue Date:	2010-09-29 11:57:43 (UTC+8)
Abstract:	中文摘要（一）前言：良性前列腺增生（benign prostatic hyperplasia, BPH），發生率隨著年齡的增加而增加，它是造成男性排尿障礙的主要原因之一。我們假設電針可以改善良性前列腺增生患者的排尿障礙。（二）目地：為了評估電針對良性前列腺增生患者的排尿困難的療效。（三）材料與方法：本研究設計採一個隨機、單盲、對照試驗。將 42位合乎收案標準的良性前列腺增生患者隨機分成二組，每組21人如下：1) 電針組，接受每週2次，每次20分鐘，連續6週12次的2 Hz電針治療；2) 假電針組，方法同上，但無通電刺激。主要評估是根據尿流速測定儀的最大尿流速（maximal flow rate, Qmax）、平均尿流速（average flow Rate, Qave）、解尿時間（total flow time）及排尿量（void volume）之電針治療前與完成6週12次電針後的變化；次要評估是根據電針治療前及完成6週12次電針後血液前列腺特殊抗原濃度的變化，以及電針治療前、治療完成3週6次時、治療完成6週12次時之國際前列腺症狀評分表（International Prostatic Symptom Score，I-PSS）的變化。（四）結果：本研究總共有37位患有良性前列腺增生症的患者（電針組18人完成電針連續6週12次的試驗。主要評估：解尿量（voiding volume）、平均尿流速(Qave)和最大尿流速(Qmax)於完成6週12次時與電針前之數值的差，電針組的增加比假電針組大（p= 0.038, 0.026, 0.030, respectively），而解尿時間則兩組間無顯著差異（p=0.607）。次要評估：電針3週6次時和電針6週12次時的國際前列腺症狀評分表分數與電針前之分數的差異，電針組和假電針組相似（p= 0.314, 0.175）。電針前與電針6週12次時血中前列腺特殊抗原值之差，兩組之間無顯著差異（p＝0.573）。（五）結論：電針有助於良性前列腺肥大患者的排尿功能，但長期追蹤療效仍是必要的。 Abstract Introduction: The incidence of Benign prostatic hyperplasia (BPH) is increase following with increasing age, and that is one of main etiology of dysuria in male. We hypothesize that electroacupuncture (EA) could improve dysuria induced by BPH. Purpose: In order to investigate the effect of EA on dysuria in patients with BPH. Material and Methods: The present study designs a single-blind randomized controlled study. A total of 42 patients with BPH who qualified inclusion criteria of the trial were randomly divided into two groups of 21 patients as follows: 1) EA group, received 2 Hz EA treatment twice/week, 20 min in duration, and continuous 6 weeks total twelve times; 2) sham EA, the methods were identical the EA group, but no electric stimulation was delivered. The main measure was according to the changes of maximal flow rate (Qmax), average flow rate (Qave), total flow time (TFT) and void volume (VV) that was measured by a uroflowmetry between before EA (baseline) and after finishing continuous 6 weeks total twelve times EA., whereas the secondary measure was according to prostate special antigen (PSA) and international prostatic symptom score (IPSS). Results: A total of 37 patients with BPH finished EA treatment of 6 weeks 12 twelve times (EA group 18 patients, sham EA group 19 patients). The increase of void volume, average flow rate and maximal flow rate from baseline to finishing 6 weeks 12 times EA was greater in EA group than that in the sham EA group (p=0.038, 0.026, 0.030, respectively), while the increased of total flow time was not significant difference between EA and sham EA groups (p=0.607). The increase of I-PSS from baseline to 3 weeks 6 times EA, and from baseline to 6 weeks 12 times EA was not significant difference between EA and sham EA group (p=0.314, 0.175, respectively). In addition, the increase of PSA from baseline to 6 weeks 12 times EA also was not significant difference between EA and sham EA groups (p > 0.05). Conclusion: EA may enhance the improvement of dysuria in patients with BPH, but long-term investigation is need.
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