The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 學士後中醫學系 > 期刊論文 > Item 310903500/3196

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题名:	The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4
作者:	蘇珊玉(Shan-Yu Su);陳俊宏(Jiunn-Horng Chen);賴建成(Chien-Chen Lai);陳君明(Chun-Ming Chen);蔡輔仁(Fuu-Jen Tsai)
贡献者:	中醫學院學士後中醫學系學士班中醫診斷學科;中國附醫中醫婦科
关键词:	Fibromyalgia;Interleukin 4;Monoamine oxidase
日期:	2007-01
上传时间:	2009-08-20 18:04:44 (UTC+8)
摘要:	Because fibromyalgia (FM) is often comorbid with anxiety, and monoamine oxidase A (MAOA) was reported to be associated with anxiety, we determine if there is MAOA gene polymorphism associated with FM patients. Moreover, interleukin 4 (IL-4) was found to be an important cytokine participating in the immunologic pathway of T-helper 2 (Th-2) cells, in this study, we search if the genetic polymorphism of IL-4 intron3 could be demonstrated in FM patients. The genotype of sixty-two FM patients was compared with that of control subjects. The polymorphism of IL-4 intron3 variable number of tandem repeats (VNTR) was demonstrated by performing the genomic polymerase chain reaction (PCR) and analyzing the length of PCR product. Furthermore, the MAOA 941 G to T polymorphism was also determined by PCR-RFLP (restriction fragment length polymorphism) analysis. The MAOA 941 position genotype polymorphism between FM and control subjects was found neither statistically different in male (p=0.60) or female (p=0.52), nor total allelic frequency (p=0.52). Similarly, the difference of IL-4 intron3 polymorphism between FM and control was neither existing in genotype (p=0.06), nor allele frequency (p=0.07). The result suggests either the genetic linkage between FM and anxiety or that between FM and immunologic diseases are weak. Accordingly, the MAOA 941 position and IL-4 intron3 polymorphisms are not susceptible markers to predict FM.
關聯:	CLINICAL RHEUMATOLOGY 26(1):12~16
显示于类别:	[學士後中醫學系] 期刊論文

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