The AluI Calcitonin Receptor Gene Polymorphism (TT) Is Associated with Low Bone Mineral Density and Susceptibility to Osteoporosis in Postmenopausal Women

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Title:	The AluI Calcitonin Receptor Gene Polymorphism (TT) Is Associated with Low Bone Mineral Density and Susceptibility to Osteoporosis in Postmenopausal Women
Authors:	蔡輔仁(Fuu-Jen Tsai);陳汶吉(Chen Wen-Chi);陳慧毅(Huey-Yi Chen)*;蔡長海(Chang-Hai Tsai)
Contributors:	中醫學院學士後中醫學系學士班中醫基礎學科;中國附醫兒童醫學中心小兒遺傳科
Keywords:	AluI calcitonin receptor gene polymorphism;Bone mineral density;Polymerase chain reaction-based restriction analysis;Osteoporosis
Date:	2003
Issue Date:	2009-08-20 18:04:33 (UTC+8)
Abstract:	China Medical University Library Your Subscriptions Logo Vol. 55, No. 2, 2003 Free Abstract Article (References) Article (PDF 99 KB) Original Paper The AluI Calcitonin Receptor Gene Polymorphism (TT) Is Associated with Low Bone Mineral Density and Susceptibility to Osteoporosis in Postmenopausal Women Fuu-Jen Tsaia, Wen-Chi Chenb,e, Huey-Yi Chenc,e, Chang-Hai Tsaid Departments of aMedical Genetics, bUrology, cObstetrics and Gynecology, and dPediatrics, China Medical College Hospital, School of Medicine, China Medical College, Taichung, and eDepartment of Life Science, National Tsing Hua University, Hsinchu, Taiwan Address of Corresponding Author Gynecol Obstet Invest 2003;55:82-87 (DOI: 10.1159/000070179) goto top of page Key Words * AluI calcitonin receptor gene polymorphism * Bone mineral density * Polymerase chain reaction-based restriction analysis * Osteoporosis goto top of page Abstract Osteoporosis is a common disorder with a strong genetic component. Our aim was to evaluate the correlation of theAluI calcitonin receptor gene polymorphism to bone mineral density and their relationship to osteoporosis. We determined the AluI calcitonin receptor gene polymorphism using polymerase chain reaction-based restriction analysis in 167 postmenopausal women in Taiwan. The polymorphism was detected by the restriction enzyme AluI, where the C allele indicated the absence of the cuttable site and the T allele indicated its presence. Bone mineral density of the lumbar spine and proximal femur were measured using dual-energy X-ray absorptiometry. The allelic frequencies for the 167 postmenopausal women in Taiwan were 86.5% for C and 13.5% for T in AluI restriction fragment length polymorphisms. The prevalence of each genotype in the study population was 2.4% TT, 22.2% CT, and 75.4% CC. The three genotypic groups differed significantly in unadjusted and adjusted bone mineral density at the lumbar spine and the femoral neck. Unadjusted and adjusted bone mineral density values were lowest in women with the TT genotype. The AluI calcitonin receptor genotype showed a positive association with prevalence of osteoporosis in the subjects. That is, women with genotype TT had a greater risk for developing osteoporosis at the lumbar spine and at the femoral neck. The AluI calcitonin receptor gene polymorphism is associated with reduced bone mineral density and predisposes women to osteoporosis, but should be interpreted with caution because of the small number of subjects in the unfavorable TT genotype.
Relation:	GYNECOLOGIC AND OBSTETRIC INVESTIGATION55(00):82~87
Appears in Collections:	[School of Post-Baccalaureate Chinese Medicine] Journal articles

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