Association between the TAP1 gene codon 637 polymorphism and Graves' disease

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 學士後中醫學系 > 期刊論文 > Item 310903500/3147

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/3147

题名:	Association between the TAP1 gene codon 637 polymorphism and Graves' disease
作者:	陳榮興;陳汶吉(Chen,Wen-Chi);陳清助(Ching-Chu Chen);蔡長海;蔡輔仁(Tsai,Fuu-Jen)
贡献者:	中醫學院學士後中醫學系學士班中醫內科學科;中國附醫內科部新陳代謝科
关键词:	Codon;Graves’ disease;polymorphism;transporter associated with antigen processing
日期:	2004-11
上传时间:	2009-08-20 18:04:19 (UTC+8)
摘要:	A total of 95 patients with Graves’ disease (GD) and 105 normal healthy controls were enrolled in this study to determine how a single site polymorphism of the transporter associated with antigen processing 1 (TAP1) gene contributes to the pathogenesis of GD. The polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. Associations between GD and the two-site polymorphisms of the TAP1 gene at codons 333 and 637 were evaluated. No significant differences were revealed comparing GD patients and normal individuals for the distributions of genotypes and allelic variants at codon 333 (p=0.253 and p=0.891, respectively). By contrast, the distributions for the AA homozygote at codon 637 were reduced and those for the GA heterozygote were increased comparing the two groups (p<0.0001). The allelic analysis also demonstrated lower A and higher G allele frequencies (p=0.0008; OR=2.745, 95% CI=1.482-5.085) comparing the GD patients with the normal healthy controls. This shows that the single-site polymorphism of the TAP1 gene at codon 637 may be an indicator for predicting development of GD.
關聯:	ENDOCRINE25(2):137~140
显示于类别:	[學士後中醫學系] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	782	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....