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| 題名: | ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway |
| 作者: | (Kuo, H-P);(Lee, D-F);(Chen, C-T.);(Liu, M.);(Chou, C-K.);(Lee, H. J.);(Xie, X.);(Wei, Y.);(Xia, W);(Zhang, W.);(Yi, D.);(Yang, J-Y.);(Huang, T-H);(Yen, C-J.);(Tan, M);(Xing, G);(Zhao, Y);(Lin, C-H);(Tsai, S-F);(Fidler, I. J.);洪明奇(Mien-Chie Hung)* |
| 貢獻者: | 醫學院癌症生物學研究所;中國附醫院長室 |
| 日期: | 2010 |
| 上傳時間: | 2010-09-27 15:48:29 (UTC+8) |
| 摘要: | Mammalian target of rapamycin (mTOR) regulates various cellular functions, including tumorigenesis, and is inhibited by the tuberous sclerosis 1 (TSC1)–TSC2 complex. Here, we demonstrate that arrest-defective protein 1 (ARD1) physically interacts with, acetylates, and stabilizes TSC2, thereby repressing mTOR activity. The inhibition of mTOR by ARD1 inhibits cell proliferation and increases autophagy, thereby inhibiting tumorigenicity. Correlation between ARD1 and TSC2 abundance was apparent in multiple tumor types. Moreover, evaluation of loss of heterozygosity at Xq28 revealed allelic loss in 31% of tested breast cancer cell lines and tumor samples. Together, our findings suggest that ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development. |
| 關聯: | Science Signaling 3(108):ra9-ra9 |
| 顯示於類別: | [癌症生物學研究所] 期刊論文
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