A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation

CMUR > College of Medicine > Graduate Institute of Immunology > Journal articles > Item 310903500/31133

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/31133

Title:	A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation
Authors:	游燕伶(Yen-Ling Yu);陳怡樺(I-Hua Chen);沈冠印(Kuan-Yin Shen);黃仁勇(Ren-Yeong Huang);王武榮(Wu-Rong Wang);周正仁(Cheng-Jen Chou);張東柱(Tun-Tschu Chang);朱清良(Ching-Liang Chu)*
Contributors:	醫學院免疫學研究所
Keywords:	DC;Immunomodulation;Th2;Triterpenoid
Date:	2009-09
Issue Date:	2010-09-27 15:42:06 (UTC+8)
Abstract:	Dendritic cells (DC) play a central role in the initiation and regulation of immune responses. Increasing evidence has indicated that manipulation of DC can serve as a therapeutic mechanism for immunomodulation. In this study we tested some unique compounds isolated from Antrodia cinnamomea, a medicinal fungus in Taiwan, on mouse bone marrow-derived DC activation. A triterpenoid methyl antcinate K (me-AntK) promoted DC maturation by enhancing the expression of MHC class II, CD86, and reducing the endocytosis. TNF-α, MCP-1, and MIP-1β were secreted by DC after me-AntK treatment, indicating augmentation of innate immunity by me-AntK. Interestingly, the me-AntK-activated DC induced Ag-specific T-cell proliferation and facilitated Th2 differentiation. Examining signaling responses, we found that me-AntK treatment uniquely activated JNK and ERK in DC. Our results demonstrate that me-AntK is the first natural triterpenoid to promote the ability of DC to prime Th2 responses. This suggests that me-AntK can potentially be applied to enhance immune responses and modulate DC function in immunotherapy.
Relation:	EUROPEAN JOURNAL OF IMMUNOLOGY 39():2482-2491
Appears in Collections:	[Graduate Institute of Immunology] Journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	355	View/Open

Loading...