Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of scutellariae radix in humans

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Title:	Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of scutellariae radix in humans
Authors:	Lai, MY;Hsiu, SL;Chen, CC;Hou, YC;Chao, PDL
Contributors:	藥學院藥學系;China Med Coll, Dept Pharm, Taichung 404, Taiwan;China Med Coll, Dept Chinese Med, Taichung 404, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan
Date:	2003
Issue Date:	2010-09-24 18:56:00 (UTC+8)
Publisher:	PHARMACEUTICAL SOC JAPAN
Abstract:	Sulfotransferase (SULT) enzymes play an important role in the detoxification, metabolism and bioactivation of numerous xenobiotics, many dietary and environmental mutagens, drugs, neurotransmitters and hormones. The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in the level of enzyme activities as well as variations of biochemical and physical properties. We developed a PCR-RFLP method to analyze the frequencies of SULT1A1 and SULT1A2 alleles among cancerous patients and normal controls in Taiwan. The results showed that SULT1A11 and SULT1A21 were in positive linkage disequilibrium. Neither SULT1A13 nor SULT1A23 were found in this study. The frequencies of SULT1A12 and SULT1A22 for hepatic, colon, lung, oral, gastric, renal and cervical cancerous patients were 3.95, 5.56, 4.92, 3.84, 2.70, 7.41 and 4.50%, respectively. No statistical significance was found for these cancer patients after comparison with normal controls (4.0%) for the allelic frequencies of SULT1A12 and SULT1A22.
Relation:	BIOLOGICAL & PHARMACEUTICAL BULLETIN 26(1):79-83
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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