Comparison of metabolic pharmacokineties of baicalin and baicalein in rats

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题名:	Comparison of metabolic pharmacokineties of baicalin and baicalein in rats
作者:	Lai, MY;Hsiu, SL;Tsai, SY;Hou, YC;Chao, PDL
贡献者:	藥學院藥學系;China Med Coll, Dept Pharm, Taichung 404, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;China Med Coll, Sch Chinese Med, Taichung 404, Taiwan
日期:	2003
上传时间:	2010-09-24 18:55:56 (UTC+8)
出版者:	ROYAL PHARMACEUTICAL SOC GREAT BRITAIN
摘要:	The solid-phase microextraction (SPME) device was used as a time-weighted average (TWA) sampler for ethylene oxide. Carboxen/polydimethylsiloxane (CAR/PDMS) fiber was used and hydrogen bromide (HBr) was loaded onto the fiber. The SPME fiber assembly was then inserted into PTFE tubing to improve the wearer's acceptance as a diffusive sampler. Known concentrations of ethylene oxide around the threshold limit values (TLVs)/time-weighted average and specific relative humidities (RHs) were generated by syringe pumps in a dynamic generation system. Ethylene oxide in gas bags were also generated. An exposure chamber was designed to allow measurement of face velocities, temperatures, exposing vapor concentrations, and RHs. Gas chromatography-mass spectrometry (GC-MS) was used for sample analysis. The appropriate adsorption time for SPME coating HBr was found to be 30 s and the desorption time for 2-bromothanol formed after sampling was determined to be 5 min. The experimental sampling constant of the sampler was found to be (2.96+/-0.09)X 10(-2) cm(3)/min, while face velocity (0-0.25 m/s) as well as RHs (10-80%) were not expected to have effects on the sampler. (C) 2003 Elsevier Science B.V. All rights reserved.
關聯:	JOURNAL OF PHARMACY AND PHARMACOLOGY 55(2):205-209
显示于类别:	[藥學系暨碩博士班] 期刊論文

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