Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥學系暨碩博士班 > 期刊論文 > Item 310903500/31058

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题名:	Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats
作者:	Hsiu, SL;Hou, YC;Wang, YH;Tsao, CW;Su, SF;Chao, PDL
贡献者:	藥學院藥學系;China Med Coll, Dept Pharm, Taichung 404, Taiwan;Chang Gung Univ, Grad Inst Nat Prod, Taoyuan, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Jen Te Jr Coll Med Nursing & Management, Miaoli, Taiwan;Natl Chung Cheng Univ, Dept Clin Pharm, Tainan, Taiwan
日期:	2002
上传时间:	2010-09-24 18:55:42 (UTC+8)
出版者:	PERGAMON-ELSEVIER SCIENCE LTD
摘要:	The object of this study was to determine the incidence of p53 mutation in recurrent nasopharyngeal carcinoma refractory to radiotherapy. Study Design: Prospective study. Methods: There were 31 patients enrolled in this study between 1995 and 1998. All patients had received radiotherapy but none of them had undergone chemotherapy or local salvage surgery previously. Results. The p53 status of each tumor was analyzed by polymerase chain reaction and by sequencing of exons 5 to 8 (codons 126-306). Five (16.1%) of 31 patients had mutations in the p53 gene, of which 2 were non-sense mutations, 2 were transition mutations, and 1 was a frameshift deletion mutation. The majority of the p53 mutations were found in exon 5. There is no significant difference in the incidence of p53 mutation compared with that of the previous reports for the primary disease. Based on the clinicopathologic data, there was no specific difference found between these 5 patients and the others. Conclusions. This study shows that p53 mutation is an infrequent event and may have no essential role in recurrent nasopharyngeal carcinomas.
關聯:	LIFE SCIENCES 72(3):227-235
显示于类别:	[藥學系暨碩博士班] 期刊論文

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