High-performance liquid chromatographic method for determination of tramadol in human plasma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥學系暨碩博士班 > 期刊論文 > Item 310903500/31047

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题名:	High-performance liquid chromatographic method for determination of tramadol in human plasma
作者:	Yeh, GC;Sheu, MT;Yen, CL;Wang, YW;Liu, CH;Ho, HO
贡献者:	藥學院藥學系;Taipei Med Coll, Grad Inst Pharmaceut Sci, Taipei, Taiwan;Taipei Med Coll, Dept Pediat, Taipei, Taiwan;China Med Coll, Sch Pharm, Taichung, Taiwan
日期:	1999
上传时间:	2010-09-24 18:55:21 (UTC+8)
出版者:	ELSEVIER SCIENCE BV
摘要:	Microsatellite instability was first reported in hereditary nonpolyposis colorectal cancer (HNPCC) as well as other cancers, including endometrial and ovarian cancers. Single base repeat markers of human MSH3 and MSH6 genes were found to precipitate the action of human MSH2. The marker BAT-26 was reported to be a simple, low-cost, and rapid marker for detection replication errors (RER) and the status of colorectal cancers. We analyzed di-nucleotide repeats of the microsatellite markers (D2S123, D5S82, D5S299, D10S197, D17S791, D18S34), single base repeat markers (Delta P-3, hMSH3, hMSH6, and TGF beta-RII), and BAT-26 to evaluate microsatellite instability in cervical cancer. Altogether 80 paired cervical cancers were studied. Our results showed that microsatellite instability is not common in cervical cancer, and the mutation of the single base repeat of mismatch repair (MMR) genes (hMSH3 and hMSH6) is also uncommon, The BAT-26 is not a good marker to detect the RER status of cervical cancer.
關聯:	JOURNAL OF CHROMATOGRAPHY B 723(1月2日):247-253
显示于类别:	[藥學系暨碩博士班] 期刊論文

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