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http://ir.cmu.edu.tw/ir/handle/310903500/31044
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| 題名: | Formation of isocyanide complexes via acylation of diaminocarbene complexes |
| 作者: | Cho, JY;Chen, CL;Hsieh, TY;Kiang, FM;Lee, GH;Peng, SM;Liu, ST |
| 貢獻者: | 藥學院藥學系;Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan;China Med Coll, Dept Pharm, Taichung, Taiwan |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 18:55:15 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE SA |
| 摘要: | Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene and p-aminobenzoic acid were determined in the bacterium Helicobacter pylori collected from peptic ulcer patients. Cytosols or suspensions of H, pylori with or without specific concentrations of ibuprofen co-treatment showed different percentages of 2-aminofluorene and p-aminobenzoic acid acetylation. The data indicate that there was decreased NAT activity associated with increased levels of ibuprofen in H, pylori cytosols, Inhibition of growth studies on H, pylori demonstrated that ibuprofen elicited a dose-dependent bactericide effect in H, pylori cultures, i,e, the greater the concentration of ibuprofen, the greater the inhibition of growth to H, pylori, For the cytosol and intact bacteria examinations, the apparent values of K-m and V-max were decreased after co-treatment with 40 mu M ibuprofen, This report is the first demonstration of ibuprofen inhibition of arylamine N-acetyltransferase activity and ibuprofen inhibition of growth in the bacterium H, pylori, (C) 1998 John Wiley & Sons, Ltd. |
| 關聯: | JOURNAL OF ORGANOMETALLIC CHEMISTRY 561(1月2日):153-155 |
| 顯示於類別: | [藥學系暨碩博士班] 期刊論文
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