STUDIES ON THE IN-VITRO PERCUTANEOUS PENETRATION OF INDOMETHACIN FROM GEL SYSTEMS IN HAIRLESS MICE

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Title:	STUDIES ON THE IN-VITRO PERCUTANEOUS PENETRATION OF INDOMETHACIN FROM GEL SYSTEMS IN HAIRLESS MICE
Authors:	LIU, CH;HO, HO;HSIEH, MC;SOKOLOSKI, TD;SHEU, MT
Contributors:	藥學院藥學系;TAIPEI MED COLL,GRAD INST PHARMACEUT SCI,TAIPEI,TAIWAN;CHINA MED COLL,SCH PHARM,TAICHUNG,TAIWAN;SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406
Date:	1995
Issue Date:	2010-09-24 18:55:02 (UTC+8)
Publisher:	ROYAL PHARMACEUTICAL SOC GREAT BRITAIN
Abstract:	The effect of intravenous administration of muscimol, a GABA(A) receptor agonist, on gastric acid secretion from perfused stomach was studied in vagotomized rats anesthetized with urethane. Muscimol did not stimulate acid secretion by itself. In contrast, muscimol dose dependently potentiated acid secretion induced by pentagastrin, bethanechol and direct vagal stimulation, but not histamine. Muscimol-potentiated acid secretion induced by pentagastrin and bethanechol was not influenced by pretreatment with atropine or cimetidine, respectively. Muscimol-potentiated acid secretion evoked by direct vagal stimulation was prevented by pretreatment with proglumide, a gastrin receptor antagonist. Muscimol-potentiated acid secretion evoked by bethanechol was dose dependently prevented by bicuculline methiodide, suggesting an involvement of peripheral GABA, receptors. These results suggest that muscimol stimulates acid secretion under certain conditions, and that two mechanisms are involved in this effect. The effects of muscimol on acid secretion may be mediated by increasing the release of histamine by pentagastrin, bethanechol and direct vagal stimulation. In addition, muscimol would also be effective if muscarinic agents were already occupying muscarinic acetylcholine receptors on parietal cells.
Relation:	JOURNAL OF PHARMACY AND PHARMACOLOGY 47(5):365-372
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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