VASORELAXANT EFFECT OF EMODIN, AN ANTHRAQUINONE FROM A CHINESE HERB

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Title:	VASORELAXANT EFFECT OF EMODIN, AN ANTHRAQUINONE FROM A CHINESE HERB
Authors:	HUANG, HC;LEE, CR;CHAO, PDL;CHEN, CC;CHU, SH
Contributors:	藥學院藥學系;NATL TAIWAN UNIV, COLL MED, DEPT SURG, TAIPEI, TAIWAN;CHINA MED COLL, DEPT PHARM, TAICHUNG, TAIWAN
Date:	1991
Issue Date:	2010-09-24 18:54:45 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	The anticonvulsive, sedative and hypothermic effects of water and ethanol extracts of Periostracum Cicadae (PC), the cast off skin of Cryptotympana atrata were studied. The water-extract of whole Periostracum Cicadae (PCws) had anticonvulsive, sedative and hypothermic effects in rats. Orally, it decreased carrageenin-induced hyperthermia. The hypothermic effect of PCws was potentiated by 5-hydroxytryptophan and antagonized by p-chlorophenylalanine. PCws enhanced the decrease in locomotor activity induced by alpha-methyl-p-tyrosine or 5-hydroxytryptophan and reduced the increase in locomotor activity produced by levodopa plus benserazide or p-chlorophenylalanine. From these results, it was concluded that the sedative and hypothermic effect of PCws may be due to an increase in central serotonergic activity.
Relation:	EUROPEAN JOURNAL OF PHARMACOLOGY 205(3):289-294
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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