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| 題名: | Stimulation of intracellular Ca2+ elevation in neutrophils by thiol-oxidizing phenylarsine oxide |
| 作者: | Wang, JP;Tsai, JJ;Chen, YS;Hsu, MF |
| 貢獻者: | 藥學院藥化所;Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan;China Med Univ, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Taichung Vet Gen Hosp, Div Allergy, Dept Internal Med, Taichung, Taiwan;China Med Univ, Sch Med, Dept Biochem, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:09:41 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | There is a close correlation between long-term potentiation (LTP) in the synapses of lateral amygdala (LA) and fear conditioning in animals. We predict that reversal of LTP (depotentiation) in this area of the brain may ameliorate conditioned fear. Activation of group II metabotropic glutamate receptors (mGluR II) with DCG-IV induces depotentiation in the LA. The induction of depotentiation is independent of NMDA receptors, L-type C++ channels, and calcineurin activity, but requires presynaptic activity and extracellular Ca++. (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) depotentiation is accompanied by a decrease in the frequency but not the amplitude of miniature excitatory post-synaptic Currents (mEPSCs) and Could be mimicked by endogenously released glutamate. DCG-IV inhibited the release of glutamate evoked by 4-AP but not that evoked by ionomycin, suggesting that the effect of DCG-IV is not mediated by an action downstream of Ca++ entry. Intra-amygdala infusion of mGluR II agonist blocks the consolidation of fear memory measured with fear-potentiated startle. Taken together, the present results characterize the properties of DCG-IV depotentiation and reveal a close parallel between depotentiation in the amygdala slice and the reduction of conditioned fear in animals. |
| 關聯: | BIOCHEMICAL PHARMACOLOGY 69(8):1225-1234 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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