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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/31007
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| 題名: | Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1 |
| 作者: | Chien, WL;Liang, KC;Teng, CM;Kuo, SC;Lee, FY;Fu, WM |
| 貢獻者: | 藥學院藥化所;Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan;Natl Taiwan Univ, Dept Psychol, Taipei, Taiwan;China Med Univ, Grad Inst Pharmaceut Chem, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:09:37 (UTC+8) |
| 出版者: | BLACKWELL PUBLISHING LTD |
| 摘要: | Apolipoprotein E ( APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (chi(2) = 8.652, p = 0.013). Carriers of the epsilon 4 allele were more common in breast cancer cases than carriers of epsilon 3 allele ( p = 0.004, OR = 1.786, 95% CI: 1.197 - 2.664). In addition, the epsilon 4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111 - 0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE epsilon 4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status. |
| 關聯: | EUROPEAN JOURNAL OF NEUROSCIENCE 21(6):1679-1688 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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