Anti-allergic agents from natural sources (4): Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)

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Title:	Anti-allergic agents from natural sources (4): Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)
Authors:	Daikonya, A;Katsuki, S;Wu, JB;Kitanaka, S
Contributors:	藥學院藥化所;Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan;Natl Inst Hlth Sci, Tanegashima Expt Stn Med Plants, Kagoshima 8913604, Japan;China Med Univ, Inst Pharmaceut Chem, Taichung 404, Taiwan
Date:	2002
Issue Date:	2010-09-24 15:08:16 (UTC+8)
Publisher:	PHARMACEUTICAL SOC JAPAN
Abstract:	Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the subthreshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.
Relation:	CHEMICAL & PHARMACEUTICAL BULLETIN 50(12):1566-1569
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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