The Voltage-Aated Potassium Channel KCNQ2 in Taiwanese Children with Febrile Convulsions

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 針灸研究所 > 期刊論文 > Item 310903500/3096

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题名:	The Voltage-Aated Potassium Channel KCNQ2 in Taiwanese Children with Febrile Convulsions
作者:	周宜卿(I-Ching Chou);蔡輔仁(Fuu-Jen Tsai)*;(Chao-Ching Huang);林正介(Cheng-Chieh Lin);(Chang-Hai Tsai)
贡献者:	中醫學院針灸研究所;中國附醫兒童醫學中心小兒神經科
日期:	2002
上传时间:	2009-08-20 17:59:28 (UTC+8)
摘要:	Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the subthreshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.
關聯:	NEUROREPORT 13(15):1971~1973
显示于类别:	[針灸研究所] 期刊論文

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