2-hydroxymethyl-1-naphthol diacetate (TAC) suppresses the superoxide anion generation in rat neutrophils

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Title:	2-hydroxymethyl-1-naphthol diacetate (TAC) suppresses the superoxide anion generation in rat neutrophils
Authors:	Wang, JP;Tsao, LT;Shen, AY;Raung, SL;Chang, LC
Contributors:	藥學院藥化所;Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Foo Yin Inst Technol, Dept Biomed Sci, Kaohsiung, Taiwan
Date:	1999
Issue Date:	2010-09-24 15:07:34 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	During recent years, sintered dicalcium phosphate (SDCP) has been shown to be an effective artificial bone filler for repairing bone defects. The goal of this study was to elucidate the effect of SDCP particle size on osteoblasts. Osteoblasts were mixed and cultured with various sized SDCP particles (0.5-3.0, 37-63, 177-250, and 420-841 mu m) for 1 h, 3 h, 1 day, 3 days, and 7 days and then analyzed. The results show that the adding of smaller sized SDCP particles (0.5-3.0 and 37-63 mu m) into osteoblast culture can significantly affect the cell counts of osteoblasts. The secretion of transforming growth factor-beta 1, alkaline phosphatase, and prostaglandin E-2 in culture medium increased significantly. The changes were most significant and persisted longer in smaller particle groups. Small sintered dicalcium phosphate particles can inhibit the proliferation of the osteoblasts. The inhibitory effects of the smaller sized SDCP particles on the osteoblasts were mediated by the promotion of osteoblast differentiation and the increased synthesis of prostaglandin E-2.
Relation:	FREE RADICAL BIOLOGY AND MEDICINE 26(7月8日):1010-1018
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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