Association analysis between Tourette’s syndrome and dopamine D1 receptor gene in Taiwanese children

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 針灸研究所 > 期刊論文 > Item 310903500/3094

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/3094

题名:	Association analysis between Tourette’s syndrome and dopamine D1 receptor gene in Taiwanese children
作者:	周宜卿(I-Ching Chou);蔡長海(Chang-Hai Tsai);李正淳(Cheng-Chun Lee);郭煌宗(Haung-Tsung Kuo);許妤安(Yu-An Hsu);(Chia-Ing Li);蔡輔仁(Fuu-Jen Tsai)
贡献者:	中醫學院針灸研究所;中國附醫兒童醫學中心小兒神經科
关键词:	Tourette's syndrome;dopamine D1 receptor gene;DRD1;polymorphism
日期:	2004
上传时间:	2009-08-20 17:59:27 (UTC+8)
摘要:	Objective: Recent research suggests that Tourette's syndrome (TS) may result from a defect in the dopamine system. The dopamine 1 receptor (DRD1) gene is a candidate gene in the study of the etiology of neuropsychiatric diseases that may involve dopaminergic abnormalities. We sought to test the hypothesis that the DRD1 gene might play a role in TS. Methods: By performing an association study, we collected an independent sample of patients from the midland region of Taiwan and investigated whether DRD1 gene polymorphisms can be used as markers of susceptibility to TS. A total of 148 children with TS and 83 normal control subjects were included in the study. A polymerase chain reaction was used to identify the A/G polymorphism of the DRD1 gene. Genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were compared. Results: The results showed that genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were not significantly different. Conclusion: These data suggest that DRD1 gene may not be a useful marker for prediction of the susceptibility of TS.
關聯:	PSYCHIATRIC GENETICS14(4):219~221
显示于类别:	[針灸研究所] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	580	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....