A secoiridoid and other constituents of Gonocaryum calleryanum

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Title:	A secoiridoid and other constituents of Gonocaryum calleryanum
Authors:	Chan, YY;Leu, YL;Lin, FW;Li, CY;Wu, YC;Shi, LS;Liou, MJ;Wu, TS
Contributors:	藥學院藥化所;Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan
Date:	1998
Issue Date:	2010-09-24 15:07:09 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	An 18-month-old girl was diagnosed as having G(MI) gangliosidosis, on the basis of the clinical symptoms of muscle stiffness, developmental retardation, hepatosplenomegaly, and kyphoscoliosis and a laboratory study that revealed a deficiency in the lysosomal degradative enzyme beta-galactosidase. Magnetic resonance Tl-weighted images showed persistent hyperintensity: in the bilateral thalami, brains tem, and deep cerebellum at 14 and 18 months of age, indicating arrest of the myelination process in these areas, and that the arrest had occurred at the newborn stage. There was no myelination in the basal ganglia and diffuse leukomalacia developed in the cerebral hemispheres. Only supportive treatment was given; the patient died at 2 years of age. Myelination arrest at the newborn stage associated with progressive leukomalacia is a possible characteristic of C-MI gangliosidosis.
Relation:	PHYTOCHEMISTRY 47(6):1073-1077
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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