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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30941
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| 題名: | Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability |
| 作者: | Lee, HZ;Lin, WC;Yeh, FT;Lin, CN;Wu, CH |
| 貢獻者: | 藥學院藥化所;China Med Coll, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung, Taiwan;Kaohsiung Med Coll, Nat Prod Res Ctr, Kaohsiung, Taiwan |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 15:07:04 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | The purpose of this study was to compare the cancer risk, with chloroform exposure during showering. The study concentrated on the three major metropolitan areas of Taiwan. Total exposure was measured based on a combination of ingestion, inhalation and skin absorption. A total of 137 tap water samples were taken from 26 locations within the Taipei (north), Taichung (central) and Kaohsiung (south) areas. Analysis of VOC compounds was performed according to the US EPA Method 524. Chloroform concentrations were highest in Kaohsiung (60.19 mu g/l), followed by Taipei (18.83 mu g/l) and Taichung (17.55 mu g/l). Based on the two-resistance theory to volatilization in showers, when air flow rate is increased, chloroform concentrations in the air significantly decrease. A 10-min shower would result in chloroform exposure with a 3:4:3 ratio (ingestion, inhalation, skin absorption). However, that changes to 1:7:2 for a 20-min shower under the same conditions. The cancer risk was highest in Kaohsiung at 17.59 per million for a 10-min shower and 64.77 per million for a 20-min shower. The lowest cancer risk was found in Taichung at 4.99 and 11.50 per million for a 10- and 20-min shower, respectively. Although ingestion is commonly considered to be the primary source of exposure to chloroform from tap water, inhalation and skin absorption exposure concentrations were found to be even higher. (C) 1998 Elsevier Science B.V. All rights reserved. |
| 關聯: | EUROPEAN JOURNAL OF PHARMACOLOGY 353(2月3日):303-313 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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