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| 題名: | Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4,8-dione derivatives |
| 作者: | Chao, YH;Kuo, SC;Wu, CH;Lee, CY;Mauger, A;Sun, IC;Morris-Natschke, SL;Lee, KH |
| 貢獻者: | 藥學院藥化所;China Med Coll, Grad Inst Pharmaceut Chem, Taichung 400, Taiwan;Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA;NCI, Drug Synth & Chem Branch, NIH, Bethesda, MD 20892 USA |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 15:06:56 (UTC+8) |
| 出版者: | AMER CHEMICAL SOC |
| 摘要: | The short insulin tolerance test (SITT) is described as a simple method to measure insulin sensitivity. To investigate the safety and reproducibility of the SITT, 16 healthy volunteers underwent two SITTs within 1 week. Intravenous insulin (0.05 U kg(-1) body weight) was injected into an antecubital vein. Blood samples were collected from the contralateral antecubital vein. The insulin-induced glucose disposal rate (K-itt) was calculated from the slope of the regression line of the logarithm of blood glucose against time during the first 3-15 min. Plasma glucose concentrations fell below 2.8 mmol l(-1) in 4 of the 32 tests and below 2.2 mmol l(-1) in 1 of these 4. Five subjects had mild hypoglycaemic symptoms, three of whom had plasma glucose concentrations below 2.8 mmol l(-1) in at least one SITT. The mean K-itt was 4.2 % min(-1) (range 0.8-8.4) for the first test and 3.4 % min(-1) (range 0.1-6.8) for the second test. The mean within-subject coefficient of variation was 30.7 %. We conclude that SITT should be applied with caution especially on insulin sensitive subjects and has poor reproducibility using 0.05 U kg(-1) body weight of insulin injection, venous sampling, uncontrolled physical activity and uncontrolled dietary composition. Whether 0.1 U kg(-1) body weight of insulin injection and arterialized venous blood sampling as in the original description of this test can improve the reproducibility of the SITT needs further investigation. (C) 1998 John Wiley & Sons, Ltd. |
| 關聯: | JOURNAL OF MEDICINAL CHEMISTRY 41(23):4658-4661 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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