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| 題名: | Involvement of cyclic AMP generation in the inhibition of respiratory burst by 2-phenyl-4-quinolone (YT-1) in rat neutrophils |
| 作者: | Wang, JP;Raung, SL;Huang, LJ;Kuo, SC |
| 貢獻者: | 藥學院藥化所;Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 15:06:54 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | 2-Acetyl-4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione (9) and 2-acetyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (19), together with 10 related mono- and disubstituted derivatives, were synthesized and evaluated in vitro by NCI against eight cancer types. All compounds showed significant activity against melanoma, HL-60 leukemia, NCI-H23 non-small-cell lung cancer, OVCAR-3 ovarian cancer, and MDA-MB-435 and MDA-N breast cancer cell lines. Compound 11, 2-(1'-acetoxyethyl)-4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione, showed the highest overall potency (mean GI(50) = 40 nM). |
| 關聯: | BIOCHEMICAL PHARMACOLOGY 56(11):1505-1514 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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