Constituents and bioactive principles of Polygonum chinensis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥物化學研究所 > 期刊論文 > Item 310903500/30934

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题名:	Constituents and bioactive principles of Polygonum chinensis
作者:	Tsai, PL;Wang, JP;Chang, CW;Kuo, SC;Chao, PDL
贡献者:	藥學院藥化所;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan
日期:	1998
上传时间:	2010-09-24 15:06:50 (UTC+8)
出版者:	PERGAMON-ELSEVIER SCIENCE LTD
摘要:	Arylamine N-acetyltransferase (NAT) activity in a human liver tumor (heptoma) cell line was inhibited by vitamin C. Using high performance liquid chromatography, NAT activity on the acetylation of 2-aminofluorene and p-aminobenzoic acid was examined. Two assay systems were performed, one with cellular cytosols, the other with intact liver tumor cell suspensions. The NAT activity in a human liver tumor cell line was inhibited by vitamin C in a dose-dependent manner in both types of examined system: Le. the greater the concentration of vitamin C in the reaction, the greater the inhibition of NAT activities in both systems examined. The data also indicated that vitamin C decreased the apparent Km and Vmax of NAT enzymes from human liver tumor cells in both systems examined. This report is the first demonstration which showed vitamin C effect on human liver tumor cell NAT activity.
關聯:	PHYTOCHEMISTRY 49(6):1663-1666
显示于类别:	[藥物化學研究所] 期刊論文

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