The lack of association between febrile convulsions and polymorphisms in SCN1A

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Title:	The lack of association between febrile convulsions and polymorphisms in SCN1A
Authors:	周宜卿(I-Ching Chou);彭慶添(Ching-Tien Peng);蔡輔仁(Fuu-Jen Tsai)*;(Huang CC);施怡如(Shi YR);蔡長海(Chang-Hai Tsai)
Contributors:	中醫學院針灸研究所;中國附醫兒童醫學中心小兒神經科
Keywords:	Voltage-gated sodium channel;Febrile convulsion;SCN1A polymorphism
Date:	2003-04
Issue Date:	2009-08-20 17:59:27 (UTC+8)
Abstract:	Febrile convulsions (FCs) represent the majority of childhood seizures, and patients have a genetic predisposition to their development. The genetic susceptibility to FCs seems to involve multiple genes in most instances. Recent studies provided evidence that mutations in SCN1A represent the most frequent cause of generalized epilepsy with febrile seizures plus an autosomal-dominant epilepsy syndrome. SCN1A mutations alter channel inactivation, resulting in persistent inward sodium current. It is not known if polymorphisms in those genes involved in familial epilepsies also contribute to the pathogenesis of FCs. By performing an association study, we used single nucleotide polymorphisms to investigate the distribution of genotypes of SCN1A in patients with FCs. A total of 104 Taiwanese children with FCs and 83 normal control subjects were included in the study. Polymerase chain reaction was used to identify the A/G polymorphism of the SCN1A gene. The results showed that genotypes and allelic frequencies for the SCN1A gene polymorphisms in both groups were not significantly different. These data suggest that the SCN1A gene might not be one of the susceptibility factors for FCs. Pure FCs and febrile convulsions associated with idiopathic generalized epilepsy may not share a common genetic etiology.
Relation:	EPILEPSY RESEARCH54(1):53~57
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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