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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30929
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| 題名: | Lead determination in whole blood by graphite furnace atomic absorption spectrometry |
| 作者: | Yen, CC;Chen, WK;Hu, CC;Wei, BL;Chung, C;Kuo, SC |
| 貢獻者: | 藥學院藥化所;TA JEN PHARMACEUT COLL,DEPT ENVIRONM ENGN & HLTH,PINGTUNG,TAIWAN;NATL TSING HUA UNIV,INST NUCL SCI,HSINCHU,TAIWAN;CHINA MED COLL,INST PHARMACEUT CHEM,TAICHUNG,TAIWAN |
| 日期: | 1997 |
| 上傳時間: | 2010-09-24 15:06:41 (UTC+8) |
| 出版者: | PERKIN-ELMER CORP |
| 摘要: | Eleven chalcone derivatives have been tested for their inhibitory effects on platelet aggregation in rabbit platelet suspension and the activation of mast cells and neutrophils. Arachidonic acid-induced platelet aggregation was potently inhibited by almost all the compounds and some also had a potent inhibitory effect on collagen-induced platelet aggregation and cyclooxygenase. Some hydroxychalcone derivatives showed strong inhibitory effects on the release of beta-glucuronidase and lysozyme, and on superoxide formation by rat neutrophils stimulated with the peptide fMet-Leu-Phe (fMLP). We found that the anti-inflammatory effect of 2',5'-dihydroxychalcone was greater than that of trifluoperazine. 2',5'-Dihydroxy and 2',3,4,4'-tetrahydroxyl chalcones, even at low concentration (50 mu M), tested In platelet-rich plasma from man almost completely inhibited secondary aggregation induced by adrenaline. These results suggest that the anti-platelet effects of the chalcones are mainly a result of inhibition of thromboxane formation. |
| 關聯: | ATOMIC SPECTROSCOPY 18(2):64-69 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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