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資料載入中.....
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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30900
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| 題名: | HA-29 - AN INHIBITOR OF THROMBOXANE-A2 FORMATION WITH ANTAGONISM OF THROMBOXANE-A2 PROSTAGLANDIN ENDOPEROXIDE RECEPTOR IN RABBIT PLATELETS |
| 作者: | LIN, CH;KUO, SC;HUANG, LJ;HUANG, TF;TENG, CM |
| 貢獻者: | 藥學院藥化所;NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,1,JEN AI RD,1ST SECT,TAIPEI 10018,TAIWAN;CHINA MED COLL,INST PHARMACEUT CHEM,TAICHUNG,TAIWAN |
| 日期: | 1992 |
| 上傳時間: | 2010-09-24 15:05:44 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | Four kinin-releasing enzymes, trimucase I, II, Ill and IV, isolated from Trimeresurus mucrosquamatus venom (TMV) caused rat hind-paw swelling. Trimucase I and III were less potent than trimucase II and IV in this effect. Pretreatment with diphenhydramine or methysergide significantly reduced trimucase-induced paw swelling, while aspirin had no effect. Cellulose sulphate pretreatment suppressed the oedematous responses elicited by trimucases. The residual response was further depressed by diphenhydramine and methysergide. Trimucases also caused kinin generation in-vitro from rat plasma. This kinin-forming activity was in the order of trimucase II > IV greater-than-or-equal-to III > I > TMV. All trimucases hydrolysed chromogenic peptides N-benzoyl-Pro-Phe-Arg p-nitroanilide, N-benzoyl-Phe-Val-Arg p-nitroanilide and DL-Val-Leu-Arg p-nitroanilide; the order of this amidolytic activity was trimucase I > II > III greater-than-or-equal-to IV. These data indicate that the effects of venom kinin-releasing enzymes on plasma kininogen are not parallel to their amidolytic effects. |
| 關聯: | THROMBOSIS RESEARCH 66(1):61-73 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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