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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30889
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| 題名: | Hypolipidemic effect of Glycine tomentella root extract in hamsters |
| 作者: | Ko, YJ;Wu, YW;Lin, WC |
| 貢獻者: | 醫學院醫學系藥理學科;China Med Univ, Dept Pharmacol, Taichung, Taiwan;China Med Univ, Grad Inst Chinese Pharmaceut Sci, Taichung, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 15:04:29 (UTC+8) |
| 出版者: | WORLD SCIENTIFIC PUBL CO PTE LTD |
| 摘要: | Ding-Chuan-Tang (DCT), a traditional Chinese medicine, has been used in treatment of the bronchial asthma for several centuries. However, the therapeutic mechanism of these Chinese medicine are still far from clear. To understand the mechanism of antiasthmatic property of DCT. A guinea pig model of allergic asthma was used to investigate the effects of DCT on ovalbumin-induced early and late asthmatic responses and airway inflammation, particularly the extent of eosinophil infiltration, and examine it direct beta2-adrenoceptor agonist activity in guinea-pig isolated trachea. We had used three different protocals in ovalbumin sensitized guinea pigs by administrating 10 g/kg of DCT extracts to sensitized guinea pigs 30 min before antigen challenge (group I), 5 hr after antigen challenge (group II) and 2.5 g/kg once daily from the day of sensitization to the day of challenge. Our result showed that administration of DCT significantly inhibited the antigen induced immediate asthmatic responses (IAR) in group I and inhibited both IRA and late asthmatic responses (LAR) in actively sensitized guinea pig in group III. DCT caused concentration-dependent relaxations in strips of guinea pig trachea contracted with carbachol, however ICI-118551, a selective beta2-adrenoceptor antagonist, didn't significantly competitively inhibit the relaxations caused by DCT. Furthermore, examination of bronchoalveolar lavage fluid (BALF) revealed that DCT significantly inhibited the increase in percent of eosinophils in the airway after antigen challenge in three group. Histopathologic examination showed DCT suppressed the eosinophil infiltration into lung tissue. These results suggest that the antiasthmatic effect of DCT is mainly due to its bronchodilatation effect and its ability to inhibit the eosinophil into the airway and there is prophylactic effect of DCT on allergen-induced airway inflammation. |
| 關聯: | AMERICAN JOURNAL OF CHINESE MEDICINE 32(1):57-63 |
| 顯示於類別: | [醫學系] 期刊論文
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