Scavenging of reactive oxygen species by a urinary preparation

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Title:	Scavenging of reactive oxygen species by a urinary preparation
Authors:	Lin, WC;Lai, TY;Wu, YW
Contributors:	醫學院醫學系藥理學科;China Med Coll, Dept Pharmacol, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 15:04:03 (UTC+8)
Publisher:	INST ADV RES ASIAN SCI & MED
Abstract:	The effects of the methanolic extract of Radix Angelica Sinensis (Umbellifera) (abbreviated as RAS extract) and n-hexane fraction of RAS extract (RAS(H) fraction) on the various drugs-induced amnesia in rats were studied by using passive avoidance task. RAS extract (1 g/kg) significantly prolonged the shortened step-through latency induced by SCOP and CXM, but not PCA. Furthermore, RAS(H) fraction (1 g/kg) also significantly prolonged the shortened step-through latency induced by SCOP and CXM but not PCA. RAS extract at any dose alone did not influence the step-through latency in the training trial produced by non-shocked rats, but it plus PCA prolonged the latency compared with PCA alone. However, RAS(H) fraction (1 g/kg) prolonged the latency in the training trial produced by non-shocked rats, but it plus any induced drugs did not differ from any induced drugs alone. These results suggest that the attenuating effects of RAS extract on the various drugs-induced amnesia were related to the memory processes. n-Hexane fraction of RAS extract might be one of the active fractions of RAS extract in the treatment of amnesia.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 28(2):251-258
Appears in Collections:	[School of Medicine] Journal articles

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