Activation of beta(3)-adrenoceptors by exogenous dopamine to lower glucose uptake into rat adipocytes

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Title:	Activation of beta(3)-adrenoceptors by exogenous dopamine to lower glucose uptake into rat adipocytes
Authors:	Lee, TL;Hsu, CT;Yen, ST;Lai, CW;Cheng, JT
Contributors:	醫學院醫學系藥理學科;Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan;China Med Coll, Dept Pathol, Taichung 40421, Taiwan
Date:	1998
Issue Date:	2010-09-24 15:03:53 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Intraperitoneal administration of magnolol (25 - 100 mg/kg) produced a dose-related fall in rats' colonic temperature. The magnolol-induced hypothermia was attenuated by pretreatment with intracerebroventricular 6-hydroxydopamine (200 mu g/rat). The L-DOPA (200 mg/kg, i.p.) plus benserazide (50 mg/kg, i.p.)-induced hyperthermia was attenuated by magnolol. On the other hand, the alpha-methyltyrosine (100 mg/kg, i.p.)-induced hypothermia was potentiated by magnolol. Furthermore, magnolol (50 mg/kg, i.p.) decreased the dopamine and norepinephrine release in the hypothalamus, but did not change the concentrations for their metabolites (3,4-dihydroxyphenylacetic acid and homovanillic acid). The data suggest that magnolol decreases colonic temperature by reducing catecholaminergic activity in rat hypothalamus.
Relation:	JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM 74(2月3日):86-90
Appears in Collections:	[School of Medicine] Journal articles

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