Cutaneous nerve degeneration induced by acrylamide in mice

CMUR > College of Medicine > School of Medicine > Journal articles > Item 310903500/30848

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30848

Title:	Cutaneous nerve degeneration induced by acrylamide in mice
Authors:	Ko, MH;Chen, WP;Hsieh, ST
Contributors:	醫學院醫學系解剖學科;Natl Taiwan Univ, Coll Med, Dept Anat & Cell Biol, Taipei 10018, Taiwan;China Med Coll, Dept Anat, Taichung 40421, Taiwan;Natl Taiwan Univ Hosp, Dept Neurol, Taipei 10043, Taiwan
Date:	2000
Issue Date:	2010-09-24 15:03:18 (UTC+8)
Publisher:	ELSEVIER SCI IRELAND LTD
Abstract:	Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of arylamine carcinogens. Attenuation of liver NAT activity is related to breast and bladder cancer processes. Therefore, the effects of ellagic acid (EA) on the in vitro and in vivo N-acetylation of 2-aminofluorene (AF) were investigated in cerebrum, cerebellum and pineal gland tissues from male Sprague-Dawley rats. For in vitro examination, cytosols with or without EA (0.5-500 muM) co-treatment decreased 7-72%, 15-63% and 10-78% of AF acetylation for cerebrum, cerebellum and pineal gland tissues, respectively. For in vivo examination, EA and AF at the same time treated groups with all 3 examined tissues did show significant differences (the changes of total amounts of AF and AF metabolites based on the Anova analysis) when compared to the ones without EA cotreatment rats. The pretreatment of male rats with EA (10 mg/kg) 24 hr prior to the administration of AF (50 mg/kg) (one day of EA administration suffice to induce large changes in phase II enzyme activity) resulted in a 76% decrease in total AF and metabolites in pineal gland but did not show significant differences in cerebrum and cerebellum tissues. This is the first demonstration to show that EA decreases the N-acetylation of carcinogens in rat brain tissues.
Relation:	NEUROSCIENCE LETTERS 293(3):195-198
Appears in Collections:	[School of Medicine] Journal articles

Files in This Item:

There are no files associated with this item.

Loading...