Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells

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Title:	Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells
Authors:	Li, TM;Chen, GW;Su, CC;Lin, JG;Yeh, CC;Cheng, KC;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Univ, Dept Microbiol, Taichung 400, Taiwan;China Med Univ, Sch Chinese Med, Taichung 400, Taiwan;China Med Univ Hosp, Dept Surg, Taichung 400, Taiwan;China Med Univ Hosp, Dept Urol, Taichung 400, Taiwan;Jen Ai Hosp, Dept Surg, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 15:03:05 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	The aim of this study was to define the clinical prevalence and rate of malignancy of focal thyroid incidentaloma in a relatively large number of individuals with application of F-18-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) in asymptomatic individuals. The subjects consisted of 4803 physical check-up examinees (2638 men, 2165 women; mean age +/- SD, 52.8 +/- 9 years old) with non-specific medical history. Whole-body FDG PET was performed on all patients. Focal hypermetabolic areas of thyroid, with an intensity equal to or exceeding the level of FDG uptake in the liver, were considered abnormal and interpreted as thyroid incidentaloma. Among the 4803 FDG PET examinations, thyroid incidentaloma was present in 60 examinations, among which, 50 had further examination with ultrasound-guided fine-needle aspiration (FNA), revealing 43 benign lesions and 7 papillary carcinomas. Of 7 examinees diagnosed with cancer, 2 had lymph nodes metastasis. The mean and standard deviation of standard uptake value (SUV) in benign and carcinoma was 2.6 +/- 1.01 and 6.7 +/- 3.66, respectively. Thyroid incidentaloma identified by FDG-PET occurred with a frequency of 1.2% (60/4803). Of the thyroid incidentalomas that underwent FNA and surgery, 14% (7/50) were found to be malignant. It is possible to differentiate benign from carcinoma of thyroid incidentalomas by the increased rate of glycolysis (SUV) in the carcinoma. The small size and moderate FDG uptake of thyroid incidentalomas per se cannot guarantee low risk in incidentally found thyroid cancers.
Relation:	ANTICANCER RESEARCH 25(2A):971-979
Appears in Collections:	[School of Medicine] Journal articles

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