Induction of G(0)/G(1) arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells

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Title:	Induction of G(0)/G(1) arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells
Authors:	Chuang, JY;Tsai, YY;Chen, SC;Hsieh, TJ;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Univ, Dept Microbiol, Taichung 40402, Taiwan;China Med Univ, Sch Med Lab Sci & Biotechnol, Taichung 40402, Taiwan;Natl Kaohsiung Normal Univ, Dept Biotechnol, Kaohsiung, Taiwan;Dept Med Technol, Kaohsiung, Taiwan
Date:	2005
Issue Date:	2010-09-24 15:02:51 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Cerebrospinal fluid (CSF) amino acid concentrations were measured in 45 children with acute lymphoblastic leukemia (ALL). Central nervous system (CNS) disease was absent in 34 and present in 11 (Groups L and M, respectively) at diagnosis. Thirty-two otherwise healthy children with febrile convulsions were studied for comparison. Results from this study show that glutamine levels at Day 0 were significantly higher in patients than in controls. Patients in Group M had elevated glutamine levels compared to Group L. In comparison, at Day 14, concentrations of glutamine and asparagine decreased, while glutamic acid amounts increased significantly in Group L. Glutamine levels fell at Day 42 in Group M, which may have resulted from more intensive treatment. From this study we hypothesise that higher baseline glutamine levels are indicative of a greater risk for CNS leukemia. Large-scale prospective trials are required to confirm increased baseline CSF glutamine levels in ALL patients, to identify glutamine as a marker for CNS disease and to clarify underlying mechanisms regulating glutamine in ALL. (c) 2005 Elsevier Ltd. All rights reserved.
Relation:	IN VIVO 19(4):683-688
Appears in Collections:	[School of Medicine] Journal articles

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