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http://ir.cmu.edu.tw/ir/handle/310903500/30833
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| 題名: | Analgesic and anti-inflammatory activities of [6]-gingerol |
| 作者: | Young, HY;Luo, YL;Cheng, HY;Hsieh, WC;Liao, JC;Peng, WH |
| 貢獻者: | 藥學院中藥所;China Med Univ, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;TzuHui Inst Technol, Pingtung 926, Taiwan;Natl Sat Yat San Univ, Inst Human Resource Management, Kaohsiung 804, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:02:48 (UTC+8) |
| 出版者: | ELSEVIER SCI IRELAND LTD |
| 摘要: | Background: Although Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs) are the two major causes of gastric ulcer, their interaction remains controversial. We constructed a prospective cohort study to evaluate how these two factors influence the expression of COX-2 mRNA in gastric antral corpus mucosa, and gastric ulcer. Methods: Tissues were obtained by endoscopic biopsy of gastric antral, corpus mucosa, and gastric ulcer. The presence of H. pylori was determined by culture or histology using Giemsa stain. NSAID use was assessed by structured questionnaire and medical record review. The expression of COX-2 mRNA was detected by the TaqMan quantitative RT-PCR system. Results: H. pylori infection was associated with increased COX-2 expression only in antral mucosa (0.77 +/- 0.13 vs. 0.31 +/- 0.07, P < 0.01). NSAID use was significantly associated with decreased COX-2 expression in ulcer (4.49 +/- 1.50 vs. 9.82 +/- 2.48, P < 0.05) but not in antral or corpus mucosa. Regarding the interaction between H. pylori and NSAID, we found that H. pylori infection was associated with increased COX-2 expression in antral mucosa for both NSAID users and nonusers. In NSAID users, H. pylori infection was not associated with increased COX-2 expression in ulcer edge. Conclusion: H. pylori infection was associated with increased COX-2 expression in gastric antral mucosa for both NSAID users and nonusers, but not in gastric ulcer, where the effect of NSAID inhibition plays a major role. With these observations, we can interpret indirectly that H. pylori eradication does not interfere with gastric ulcer healing in NSAID users. |
| 關聯: | JOURNAL OF ETHNOPHARMACOLOGY 96(1月2日):207-210 |
| 顯示於類別: | [中國藥學研究所(已停用)] 期刊論文
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