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| 題名: | Oral administration of paclitaxel affects the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats |
| 作者: | Lu, KH;Lue, KH;Hsia, TC;Chou, MC;Lin, KL;Chung, JG |
| 貢獻者: | 醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;China Med Coll Hosp, Dept Internal Med, Taichung, Taiwan;Chung Shan Med Univ, Sch Med Technol & Optometry, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:02:41 (UTC+8) |
| 出版者: | URBAN & FISCHER VERLAG |
| 摘要: | The anti-inflammatory activities of five flavonoids, namely 5,7-dimethoxyflavanone (1), 5,7-dimethoxy-3',4'-methylenedioxyflavanone (2), isobonducellin (3), 2'-hydroxy-2,3,4',6'-tetramethoxychalcone (4) and bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages. These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha. and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3 > 5 > 4 > 2 > 1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-gamma for 24 h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24 h. The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities. (C) 2005 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | PHYTOMEDICINE 12(8):577-587 |
| 顯示於類別: | [醫學系] 期刊論文
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