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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30820
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| 題名: | Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives |
| 作者: | Rao, YK;Fang, SH;Tzeng, YM |
| 貢獻者: | 醫學院醫學系微生物學科;Chaoyang Univ Technol, Inst Biotechnol, Wufeng 413, Taiwan;China Med Univ, Dept Microbiol, Sch Med, Taichung 400, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:02:30 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | The aim of this study was to evaluate the potential role of positron emission tomography (PET) with F-18-fluorodemyglucose (FDG) in patients with unexplained rising serum alpha -fetoprotein (AFP) levels after the treatment of hepatocellular carcinoma (HCC). Patients and Methods: Thirty-one FDG-PET studies were performed in 26 Patients (age ranged 45-83; 21 men and 5 women), who had undergone either surgical resection or interventional therapy for HCC, but were subsequently, noted to have high AFP serum levels on routine follow-up examinations, although imaging studies and physical examinations were normal. The FDG-PET results were correlated with histological findings, as well as long-term radiological and clinical follow-tip (shortest follow-up period after FDG-PET was 6 months). Results: FDG-PET was abnormal in 22 of the 31 studies (71.0%) among the 26 patients. Intrahepatic lesions were detected in 20 of a total 30 lesions (66.7%) in 18 studies of FDG-PET among 26 patients. Ten FDG-PET studies among 9 patients identified one intrahepatic lesion, while 3 studies among 3 patients identified more than one intrahepatic lesion. Extrahepatic melastases were found in 9131 studies of FDG-PET (29.0%) among 8 patients. These metastatic foci, composed of increased FDG accumulation, were identified in several locations; lung (4 studies among 4 patients), bone (2 studies among 2 patients) and the peritoneum (4 studies among 3 patients). Overall, FDG-PET for detecting HCC recurrence demonstrated 22 true-positives, 8 false-negatives, I true-negative and 0 false-positive results. The sensitivity, specificity and accuracy of FDG-PET for detecting HCC recurrence was 73.3%, 100% and 74.2%, respectively. Conclusion: When conventional examinations are normal, FDG-PET is a valuable imaging tool in patients who have rising AFP levels after HCC treatment. FDG-PET whole-body scan also provides ail important and valuable imaging study for detecting extrahepatic metastasis. |
| 關聯: | BIOORGANIC & MEDICINAL CHEMISTRY 13(24):6850-6855 |
| 顯示於類別: | [醫學系] 期刊論文
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