Evaluation of antinociceptive, anti-inflammatory and antipyretic effects of Strobilanthes cusia leaf extract in male mice and rats

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题名:	Evaluation of antinociceptive, anti-inflammatory and antipyretic effects of Strobilanthes cusia leaf extract in male mice and rats
作者:	Ho, YL;Kao, KC;Tsai, HY;Chueh, FY;Chang, YS
贡献者:	藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Hungkuang Inst Technol, Dept Nursing, Taichung 433, Taiwan;China Med Coll Hosp, Dept Pharm, Taichung 404, Taiwan
日期:	2003
上传时间:	2010-09-24 15:02:06 (UTC+8)
出版者:	WORLD SCIENTIFIC PUBL CO PTE LTD
摘要:	Objective: This study was desioned to test the hypotheses that local somatothermal stimulation on the left median nerve territory increases myocardial heat shock protein 70 and that preconditioning of rats with local somatothermal Stimulation protects the hearts against subsequent ischemia-reperfusion injury. Methods: Local somatothermal stimulation was brought about by means of application of a heating rod over and above the left median nerve territory (1.5 cm proximal to the palm crease) in male Sprague-Dawley rats. After rats were treated with local somatothermal stimulation, the gene expression of heat shock protein 70 in regional muscle, heart, and liver was assessed by means of Western blotting and reverse transcription-polymerase chain reaction. In addition, durations of arrhythmia, mortality rates, and mitochondrial functions were compared between groups preconditioned with or without local somatothermal stimulation followed by subsequent myocardial ischemia-reperfusion injury. Results: The results showed that the gene expression of heat shock protein 70 was upregulated in the muscle beneath the area of local somatothermal stimulation, as well as in the heart, although not in the liver. When animals were preconditioned with local somatothermal stimulation on the left median nerve territory followed by subsequent ischemia-reperfusion injury of the heart, there were significant decreases of creatine kinase level from the heart, duration of arrhythmia, mortality rate, and improved initochondrial respiratory function compared with that seen in those without local somatothermal stimulation preconditioning. Conclusion: We conclude that local heat stress preconditioning on the left median nerve territory has a potential cardioprotective effect against subsequent ischemia-reperfusion injury.
關聯:	AMERICAN JOURNAL OF CHINESE MEDICINE 31(1):61-69
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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