Incorporation of DNA chip technology to the simulation and validation of flux analysis in yeast diauxic growth

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Title:	Incorporation of DNA chip technology to the simulation and validation of flux analysis in yeast diauxic growth
Authors:	Huang, GWS;Hong, MY;Liu, YC
Contributors:	藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Natl Chung Hsing Univ, Dept Chem Engn, Taichung 402, Taiwan
Date:	2003
Issue Date:	2010-09-24 15:02:02 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	Objective. To explore the factors influencing serum uric acid concentrations and the prevalence of hyperuricemia in aboriginal children from an area in Taiwan with a high prevalence of gouty arthritis. Methods: A cross sectional study of the Bunun tribe was conducted in central Taiwan from March to May 2001. Children aged 4-13 were requested to fill out a structured questionnaire with the assistance of their parents. A total of 414 children (mean age, 8.9 +/- 2.1 yrs) were recruited. Uric acid was determined by colorimetry using the uricase method. Since no previous study has investigated serum uric acid concentrations in these aboriginal children, hyperuricemia was defined as uric acid > 416.5 mumol/1 (7 mg/dl) in boys and > 357 mumol/I (6 mg/dl) in girls. Results. The mean concentration of serum uric acid was 368.9 +/- 83.3 mumol/1. Ninety of 224 girls (40.2%) and 56 of 190 boys (29.5%) were hyperuricemic. Children with hyperuricemia had significantly higher body mass index (BMI), blood pressure, and triglyceride and creatinine concentrations than those with normal uric acid concentrations. After adjustment for age, sex, lipid profile, and blood pressure, hyperuricemia was found to be significantly associated with serum creatinine (OR 2.40, 95% CI 1.91-3.04), BMI (OR 1.24, 95% CI 1.11-1.40), and a family history of gouty arthritis, in parents (OR 2.01, 95% CI 1.02-3.96). Conclusion. BMI, a positive family history of gouty arthritis in parents, and creatinine level correlated with hyperuricemia in aboriginal children in Taiwan.
Relation:	LIFE SCIENCES 72(22):2525-2531
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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